                         SEQUENCE LISTING

<110>  Verra Therapeutics
       Moss, Marcia L.
       Rasmussen, Robert
       Prince, Chris
 
<120>  METHODS AND COMPOSITIONS FOR INHIBITING ADAM10 BIOLOGICAL 
       ACTIVITIES

<130>  3217/2 PCT

<150>  US 62/566,580
<151>  2017-10-02

<150>  US 62/589,842
<151>  2017-11-22

<160>  71814 

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2
<211>  190
<212>  PRT
<213>  Mus musculus

<400>  2

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Leu Leu Asp Phe His Ala His Gly Arg Gln 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Lys Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Ile Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Ile Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Gly Ala Arg Ala His Pro 
                165                 170                 175     


Glu Lys His Ala Ala Ser Ser Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 190 


<210>  3
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially created consensus sequence


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be Arg, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be Ala, Arg, or Lys

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be Lys, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be Arg, Ala, Ser, Gly, Thr, or Lys

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  Xaa can be Glu, Asp, Gln, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be Arg, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be Met, Arg, or Lys

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be Lys, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be Arg, Ala, Ser, Gly, Thr, or Lys

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  Xaa can be Asp, Glu, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (88)..(89)
<223>  Xaa can be Glu, Ala, Ser, Gly, Thr, or Asn
<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  Xaa can be Glu, Asp, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  Xaa can be Cys, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (169)..(170)
<223>  Xaa can be Glu, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (176)..(178)
<223>  Xaa can be Glu, Gln, Ala, Ser, Gly, Thr, or Asn


<400>  3

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Xaa Xaa Xaa Xaa Ala Val Ser 
            20                  25                  30          


His Xaa Xaa Xaa Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Xaa Xaa Xaa Xaa Asp Thr Ser Leu Phe Ser Xaa Xaa Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Xaa Xaa Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Xaa Xaa Xaa Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Xaa Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Xaa Xaa Val Thr Gln Ile Pro Xaa 
                165                 170                 175     


Xaa Xaa His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially created consensus sequence


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can Arg, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be Ala, Arg, or Lys

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be Lys, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be Arg, Ala, Ser, Gly, Thr, or Lys

<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  Xaa can be Glu, Asp, Gln, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be Arg, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be Met, Arg, or Lys

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be Lys, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be Arg, Ala, Ser, Gly, Thr, or Lys

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  Xaa can be Asp, Glu, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (88)..(89)
<223>  Xaa can be Glu, Ala, Ser, Gly, Thr, or Asn
<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  Xaa can be Glu, Asp, Ala, Ser, Gly, Thr, or Asn

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  Xaa can be Cys, Ala, Ser, Gly, or Thr

<220>
<221>  misc_feature
<222>  (169)..(170)
<223>  Xaa can be Glu, Ala, Ser, Gly, Thr, or Asn

<400>  4

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Xaa Xaa Xaa Xaa Ala Val Ser 
            20                  25                  30          


His Xaa Xaa Xaa Phe Leu Leu Leu Asp Phe His Ala His Gly Arg Gln 
        35                  40                  45              


Phe Asn Leu Xaa Xaa Xaa Xaa Asp Thr Ser Leu Phe Ser Xaa Xaa Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Xaa Xaa Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Lys Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Ile Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Ile Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Xaa Xaa Xaa Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Xaa Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Xaa Xaa Gly Ala Arg Ala His Pro 
                165                 170                 175     


Glu Lys His Ala Ala Ser Ser Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 190   


<210>  5
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  19
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  19

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  20
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  20

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  21
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  21

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  22
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  22

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  23
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  23

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  24
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  24

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr Asp Asp Ile Asn Tyr Pro His Lys Tyr Gly 
    130                 135                 140                 


Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met Arg Lys 
145                 150                 155                 160 


Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln Glu Glu 
                165                 170                 175     


His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185         


<210>  25
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  25

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  26
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  26

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  27
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  27

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  28
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  28

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  29
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  29

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  30
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  30

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  31
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  31

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  32
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  32

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  33
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  33

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  34
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  34

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  35
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  35

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  36
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  36

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  37
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  37

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  38
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  38

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  39
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  39

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  40
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  40

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  41
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  41

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Glu Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  42
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  42

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  43
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  43

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  44
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  44

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  45
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  45

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  46
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  46

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  47
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  47

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  48
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  48

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  49
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  49

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  50
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  50

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  51
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  51

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  52
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  52

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys Tyr Gly Glu 
            180                 185                 190         


Glu Gly Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly 
        195                 200                 205             


Phe Ile Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg 
    210                 215                 220                 


Tyr Ile Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu 
225                 230                 235                 240 


Asp Asp Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Ser Ala 
                245                 250                 255     


Asp His Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val 
            260                 265                 270         


Glu Glu Val Thr Gln Ile Pro Gln Ala Glu His Ala Ala Asn Gly Pro 
        275                 280                 285             


Glu Leu Leu Arg Lys 
    290             


<210>  53
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  53

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  54
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  54

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  55
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  55

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  56
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  56

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  57
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  57

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  58
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  58

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  59
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  59

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  60
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  60

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  61
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  61

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  62
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  62

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  63
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  63

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  64
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  64

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Leu Leu Asp Phe His Ala His Gly Arg Gln 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Lys Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Ile Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Ile Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Gly Ala Arg Ala His Pro 
                165                 170                 175     


Glu Lys His Ala Ala Ser Ser Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 190 

<210>  65
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  65

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  66
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  66

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Leu Leu Asp Phe His Ala His Gly Arg Gln 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Pro Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Lys Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Ile Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Ile Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  67
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  67

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Gly Ala Arg Ala His Pro 
                165                 170                 175     


Glu Lys His Ala Ala Ser Ser Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 190 


<210>  68
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  68

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  69
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  69

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  70
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  70

Cys Gly Ser Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu 
1               5                   10                  15      


Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys 
            20                  25                  30          


Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His 
        35                  40                  45              


Gly Arg His Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser 
    50                  55                  60                  


Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr 
65                  70                  75                  80  


Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser 
                85                  90                  95      


His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg 
            100                 105                 110         


Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg 
        115                 120                 125             


Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr 
    130                 135                 140                 


Pro His Lys Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe 
145                 150                 155                 160 


Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln 
                165                 170                 175     


Ile Pro Gln Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 190         


<210>  71
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  71

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys Gly Ser Gly 
            180                 185                 190         


Ser Cys 
        


<210>  72
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  72

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  73
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  73

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  74
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  74

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  75
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  75

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  76
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  76

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  77
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  77

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  78
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  78

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  79
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  79

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  80
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  80

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  81
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  81

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  82
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  82

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  83
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  83

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  84
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  84

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  85
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  85

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  86
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  86

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  87
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  87

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  88
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  88

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  89
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  89

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  90
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  90

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  91
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  91

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  92
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  92

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  93
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  93

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  94
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  94

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  95
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  95

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  96
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  96

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  97
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  97

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  98
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  98

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  99
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  99

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  1999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  1999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  2999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  2999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  3999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  3999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  4999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  4999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Ala Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Ala Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Ala Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Lys Ala Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Lys Met Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Arg Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  5999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  5999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Arg Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Ala Lys Lys Arg Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Met Lys Lys Arg Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Arg Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Lys Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Arg Lys Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  6999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  6999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  7999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  7999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  8999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  8999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  9999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  9999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  10999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  10999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  11999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  11999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  12999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  12999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  13999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  13999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Gln Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  14999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  14999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  15999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  15999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  16999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  16999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17717
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17717

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17718
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17718

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17719
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17719

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17720
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17720

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17721
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17721

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17722
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17722

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17723
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17723

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17724
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17724

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17725
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17725

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17726
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17726

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17727
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17727

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17728
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17728

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17729
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17729

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17730
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17730

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17731
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17731

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17732
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17732

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17733
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17733

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17734
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17734

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17735
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17735

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17736
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17736

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17737
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17737

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17738
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17738

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17739
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17739

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17740
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17740

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17741
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17741

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17742
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17742

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17743
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17743

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17744
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17744

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17745
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17745

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17746
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17746

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17747
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17747

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17748
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17748

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17749
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17749

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17750
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17750

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17751
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17751

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17752
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17752

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17753
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17753

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17754
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17754

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17755
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17755

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17756
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17756

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17757
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17757

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17758
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17758

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17759
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17759

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17760
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17760

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17761
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17761

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17762
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17762

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17763
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17763

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17764
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17764

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17765
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17765

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17766
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17766

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17767
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17767

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17768
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17768

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17769
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17769

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17770
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17770

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17771
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17771

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17772
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17772

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17773
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17773

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17774
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17774

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17775
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17775

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17776
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17776

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17777
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17777

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17778
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17778

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17779
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17779

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17780
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17780

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17781
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17781

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17782
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17782

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17783
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17783

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17784
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17784

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17785
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17785

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17786
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17786

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17787
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17787

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17788
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17788

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17789
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17789

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17790
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17790

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17791
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17791

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17792
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17792

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17793
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17793

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17794
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17794

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17795
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17795

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17796
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17796

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17797
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17797

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17798
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17798

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17799
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17799

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17800
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17800

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17801
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17801

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17802
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17802

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17803
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17803

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17804
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17804

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17805
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17805

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17806
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17806

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17807
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17807

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17808
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17808

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17809
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17809

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17810
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17810

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17811
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17811

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17812
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17812

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17813
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17813

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17814
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17814

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17815
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17815

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17816
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17816

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17817
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17817

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17818
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17818

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17819
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17819

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17820
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17820

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17821
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17821

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17822
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17822

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17823
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17823

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17824
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17824

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17825
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17825

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17826
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17826

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17827
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17827

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17828
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17828

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17829
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17829

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17830
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17830

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17831
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17831

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17832
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17832

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17833
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17833

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17834
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17834

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17835
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17835

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17836
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17836

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17837
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17837

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17838
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17838

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17839
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17839

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17840
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17840

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17841
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17841

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17842
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17842

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17843
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17843

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17844
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17844

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17845
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17845

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17846
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17846

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17847
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17847

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17848
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17848

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17849
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17849

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17850
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17850

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17851
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17851

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17852
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17852

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17853
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17853

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17854
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17854

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17855
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17855

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17856
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17856

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17857
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17857

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17858
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17858

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17859
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17859

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17860
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17860

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17861
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17861

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17862
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17862

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17863
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17863

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17864
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17864

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17865
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17865

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17866
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17866

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17867
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17867

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17868
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17868

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17869
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17869

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17870
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17870

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17871
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17871

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17872
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17872

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17873
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17873

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17874
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17874

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17875
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17875

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17876
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17876

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17877
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17877

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17878
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17878

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17879
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17879

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17880
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17880

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17881
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17881

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17882
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17882

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17883
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17883

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17884
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17884

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17885
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17885

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17886
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17886

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17887
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17887

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17888
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17888

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17889
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17889

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17890
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17890

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17891
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17891

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17892
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17892

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17893
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17893

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17894
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17894

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17895
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17895

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17896
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17896

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17897
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17897

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17898
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17898

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17899
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17899

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17900
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17900

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17901
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17901

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17902
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17902

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17903
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17903

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17904
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17904

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17905
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17905

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17906
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17906

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17907
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17907

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17908
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17908

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17909
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17909

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17910
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17910

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17911
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17911

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17912
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17912

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17913
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17913

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17914
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17914

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17915
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17915

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17916
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17916

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17917
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17917

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17918
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17918

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17919
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17919

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17920
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17920

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17921
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17921

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17922
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17922

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17923
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17923

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17924
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17924

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17925
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17925

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17926
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17926

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17927
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17927

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17928
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17928

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17929
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17929

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17930
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17930

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17931
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17931

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17932
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17932

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17933
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17933

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17934
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17934

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17935
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17935

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17936
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17936

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17937
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17937

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17938
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17938

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17939
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17939

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17940
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17940

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17941
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17941

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17942
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17942

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17943
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17943

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17944
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17944

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17945
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17945

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17946
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17946

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17947
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17947

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17948
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17948

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17949
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17949

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17950
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17950

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17951
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17951

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17952
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17952

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17953
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17953

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17954
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17954

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17955
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17955

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17956
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17956

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17957
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17957

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17958
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17958

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17959
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17959

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17960
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17960

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17961
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17961

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17962
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17962

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17963
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17963

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17964
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17964

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17965
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17965

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17966
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17966

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17967
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17967

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17968
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17968

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17969
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17969

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17970
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17970

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17971
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17971

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17972
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17972

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17973
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17973

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17974
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17974

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17975
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17975

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17976
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17976

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17977
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17977

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17978
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17978

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17979
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17979

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17980
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17980

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17981
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17981

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17982
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17982

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17983
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17983

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17984
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17984

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17985
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17985

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17986
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17986

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17987
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17987

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17988
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17988

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17989
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17989

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17990
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17990

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17991
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17991

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17992
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17992

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17993
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17993

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17994
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17994

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17995
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17995

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17996
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17996

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17997
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17997

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17998
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17998

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  17999
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  17999

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18000
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18000

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18001
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18001

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18002
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18002

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18003
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18003

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18004
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18004

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18005
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18005

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18006
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18006

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18007
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18007

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18008
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18008

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18009
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18009

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18010
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18010

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18011
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18011

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18012
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18012

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18013
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18013

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18014
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18014

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18015
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18015

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18016
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18016

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18017
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18017

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18018
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18018

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18019
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18019

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18020
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18020

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18021
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18021

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18022
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18022

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18023
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18023

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18024
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18024

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18025
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18025

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18026
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18026

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18027
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18027

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18028
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18028

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18029
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18029

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18030
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18030

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18031
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18031

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18032
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18032

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18033
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18033

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18034
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18034

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18035
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18035

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18036
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18036

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18037
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18037

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18038
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18038

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18039
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18039

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18040
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18040

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18041
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18041

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18042
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18042

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18043
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18043

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18044
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18044

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18045
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18045

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18046
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18046

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18047
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18047

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18048
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18048

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18049
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18049

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18050
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18050

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18051
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18051

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18052
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18052

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18053
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18053

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18054
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18054

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18055
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18055

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18056
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18056

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18057
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18057

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18058
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18058

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18059
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18059

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18060
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18060

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18061
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18061

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18062
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18062

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18063
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18063

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18064
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18064

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18065
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18065

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18066
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18066

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18067
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18067

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18068
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18068

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18069
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18069

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18070
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18070

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18071
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18071

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18072
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18072

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18073
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18073

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18074
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18074

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18075
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18075

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18076
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18076

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18077
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18077

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18078
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18078

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18079
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18079

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18080
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18080

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18081
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18081

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18082
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18082

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18083
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18083

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18084
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18084

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18085
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18085

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18086
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18086

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18087
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18087

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18088
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18088

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18089
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18089

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18090
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18090

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18091
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18091

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18092
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18092

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18093
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18093

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18094
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18094

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18095
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18095

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18096
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18096

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18097
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18097

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18098
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18098

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18099
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18099

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18100
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18100

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18101
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18101

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18102
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18102

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18103
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18103

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18104
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18104

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18105
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18105

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18106
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18106

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18107
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18107

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18108
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18108

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18109

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18110
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18110

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18111
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18111

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18112
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18112

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18113
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18113

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18114
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18114

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18115
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18115

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18116
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18116

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18117
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18117

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18118
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18118

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18119
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18119

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18120
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18120

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18121
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18121

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18122
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18122

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18123
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18123

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18124
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18124

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18125
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18125

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18126
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18126

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18127
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18127

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18128
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18128

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18129
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18129

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18130
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18130

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18131
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18131

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18132
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18132

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18133
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18133

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18134
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18134

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18135
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18135

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18136
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18136

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18137

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18138
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18138

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18139
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18139

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18140
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18140

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18141
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18141

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18142
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18142

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18143
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18143

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18144
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18144

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18145
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18145

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18146
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18146

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18147
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18147

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18148
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18148

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18149
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18149

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18150
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18150

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18151
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18151

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18152
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18152

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18153
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18153

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18154
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18154

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18155
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18155

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18156
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18156

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18157
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18157

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18158
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18158

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18159
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18159

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18160
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18160

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18161
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18161

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18162
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18162

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18163
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18163

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18164
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18164

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18165
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18165

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18166
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18166

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18167
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18167

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18168
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18168

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18169
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18169

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18170
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18170

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18171
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18171

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18172
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18172

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18173
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18173

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18174
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18174

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18175
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18175

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18176
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18176

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18177
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18177

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18178
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18178

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18179
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18179

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18180
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18180

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18181
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18181

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18182
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18182

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18183
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18183

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18184
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18184

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18185
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18185

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18186
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18186

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18187
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18187

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18188
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18188

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18189
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18189

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18190
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18190

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18191
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18191

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18192
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18192

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18193
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18193

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18194
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18194

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18195
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18195

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18196
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18196

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18197
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18197

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18198
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18198

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18199
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18199

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18200
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18200

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18201
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18201

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18202
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18202

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18203
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18203

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18204
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18204

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18205
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18205

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18206
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18206

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18207
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18207

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18208
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18208

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18209
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18209

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18210
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18210

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18211
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18211

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18212
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18212

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18213
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18213

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18214
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18214

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18215
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18215

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18216
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18216

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18217
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18217

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18218
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18218

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18219
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18219

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18220

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18221
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18221

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18222
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18222

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18223

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18224
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18224

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18225
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18225

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18226
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18226

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18227
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18227

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18228
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18228

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18229
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18229

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18230
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18230

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18231
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18231

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18232
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18232

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18233
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18233

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18234
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18234

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18235
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18235

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18236
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18236

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18237
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18237

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18238
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18238

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18239
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18239

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18240
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18240

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18241
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18241

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18242
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18242

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18243
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18243

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18244
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18244

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18245
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18245

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18246
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18246

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18247
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18247

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18248
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18248

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18249
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18249

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18250
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18250

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18251
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18251

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18252
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18252

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18253
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18253

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18254
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18254

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18255
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18255

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18256
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18256

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18257
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18257

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18258
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18258

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18259
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18259

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18260
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18260

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18261
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18261

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18262
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18262

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18263
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18263

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18264
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18264

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18265
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18265

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18266
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18266

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18267
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18267

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18268
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18268

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18269
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18269

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18270
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18270

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18271
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18271

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18272
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18272

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18273
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18273

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18274
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18274

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18275
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18275

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18276
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18276

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18277
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18277

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18278
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18278

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18279
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18279

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18280
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18280

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18281
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18281

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18282
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18282

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18283
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18283

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18284
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18284

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18285
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18285

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18286
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18286

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18287
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18287

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18288
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18288

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18289
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18289

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18290
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18290

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18291
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18291

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18292
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18292

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18293
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18293

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18294
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18294

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18295
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18295

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18296
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18296

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18297
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18297

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18298
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18298

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18299
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18299

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18300
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18300

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18301
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18301

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18302
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18302

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18303
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18303

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18304
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18304

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18305
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18305

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18306
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18306

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18307
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18307

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18308
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18308

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18309
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18309

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18310
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18310

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18311
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18311

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18312
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18312

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18313
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18313

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18314
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18314

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18315
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18315

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18316
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18316

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18317
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18317

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18318
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18318

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18319
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18319

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18320
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18320

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18321
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18321

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18322
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18322

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18323
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18323

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18324
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18324

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18325
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18325

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18326
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18326

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18327
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18327

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18328
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18328

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18329
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18329

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18330
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18330

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18331
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18331

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18332
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18332

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18333
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18333

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18334
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18334

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18335
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18335

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18336
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18336

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18337
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18337

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18338
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18338

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18339
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18339

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18340
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18340

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18341
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18341

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18342
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18342

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18343
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18343

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18344
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18344

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18345
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18345

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18346
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18346

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18347
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18347

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18348
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18348

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18349
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18349

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18350
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18350

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18351
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18351

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18352
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18352

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18353
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18353

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18354
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18354

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18355
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18355

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18356
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18356

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18357
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18357

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18358
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18358

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18359
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18359

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18360
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18360

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18361
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18361

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18362
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18362

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18363
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18363

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18364
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18364

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18365
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18365

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18366
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18366

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18367
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18367

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18368
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18368

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18369
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18369

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18370
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18370

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18371
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18371

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18372
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18372

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18373
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18373

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18374
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18374

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18375
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18375

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18376
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18376

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18377
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18377

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18378
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18378

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18379
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18379

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18380
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18380

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18381
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18381

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18382
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18382

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18383
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18383

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18384
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18384

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18385
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18385

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18386
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18386

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18387
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18387

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18388
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18388

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18389
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18389

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18390
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18390

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18391
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18391

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18392
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18392

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18393
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18393

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18394
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18394

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18395
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18395

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18396
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18396

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18397
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18397

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18398
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18398

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18399
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18399

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18400
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18400

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18401
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18401

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18402
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18402

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18403
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18403

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18404
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18404

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18405
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18405

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18406
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18406

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18407
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18407

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18408
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18408

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18409
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18409

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18410
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18410

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18411
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18411

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18412
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18412

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18413
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18413

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18414
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18414

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18415
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18415

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18416
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18416

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18417
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18417

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18418
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18418

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18419
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18419

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18420
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18420

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18421
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18421

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18422
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18422

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18423
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18423

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18424
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18424

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18425
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18425

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18426
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18426

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18427
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18427

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18428
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18428

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18429
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18429

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18430
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18430

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18431
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18431

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18432
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18432

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18433
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18433

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18434
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18434

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18435
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18435

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18436
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18436

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18437
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18437

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18438
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18438

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18439
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18439

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18440
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18440

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18441
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18441

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18442
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18442

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18443
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18443

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18444
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18444

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18445
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18445

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18446
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18446

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18447
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18447

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18448
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18448

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18449
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18449

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18450
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18450

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18451
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18451

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18452
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18452

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18453
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18453

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18454
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18454

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18455
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18455

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18456
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18456

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18457
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18457

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18458
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18458

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18459
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18459

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18460
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18460

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18461
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18461

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18462
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18462

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18463
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18463

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18464
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18464

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18465
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18465

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18466
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18466

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18467
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18467

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18468
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18468

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18469
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18469

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18470
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18470

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18471
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18471

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18472
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18472

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18473
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18473

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18474
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18474

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18475
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18475

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18476
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18476

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18477
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18477

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18478
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18478

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18479
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18479

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18480
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18480

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18481
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18481

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18482
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18482

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18483
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18483

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18484
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18484

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18485
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18485

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18486
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18486

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18487
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18487

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18488
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18488

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18489
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18489

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18490
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18490

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18491
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18491

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18492
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18492

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18493
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18493

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18494
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18494

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18495
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18495

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18496
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18496

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18497
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18497

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18498
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18498

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18499
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18499

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18500
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18500

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18501
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18501

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18502
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18502

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18503
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18503

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18504
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18504

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18505
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18505

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18506
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18506

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18507
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18507

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18508
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18508

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18509
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18509

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18510
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18510

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18511
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18511

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18512
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18512

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18513
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18513

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18514
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18514

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18515
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18515

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18516
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18516

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18517
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18517

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18518
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18518

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18519
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18519

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18520
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18520

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18521
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18521

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18522
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18522

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18523
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18523

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18524
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18524

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18525
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18525

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18526
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18526

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18527
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18527

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18528
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18528

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18529
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18529

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18530
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18530

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18531
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18531

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18532
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18532

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18533
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18533

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18534
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18534

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18535
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18535

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18536
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18536

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18537
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18537

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18538
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18538

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18539
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18539

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18540
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18540

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18541
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18541

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18542
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18542

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18543
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18543

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18544
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18544

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18545
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18545

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18546
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18546

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18547
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18547

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18548
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18548

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18549
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18549

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18550
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18550

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18551
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18551

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18552
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18552

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18553
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18553

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18554
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18554

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18555
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18555

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18556
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18556

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18557
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18557

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18558
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18558

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18559
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18559

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18560
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18560

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18561
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18561

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18562
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18562

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18563
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18563

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18564
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18564

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18565
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18565

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18566
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18566

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Asp Ala Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Ala Ala Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Ala Ala Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18567
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18567

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18568
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18568

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18569
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18569

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18570
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18570

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18571
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18571

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18572
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18572

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18573
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18573

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18574
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18574

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18575
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18575

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18576
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18576

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18577
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18577

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18578
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18578

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18579
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18579

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18580
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18580

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18581
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18581

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18582
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18582

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18583
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18583

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18584
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18584

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18585
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18585

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18586
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18586

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18587
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18587

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18588
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18588

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18589
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18589

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18590
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18590

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18591
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18591

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18592
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18592

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18593
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18593

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18594
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18594

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18595
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18595

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18596
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18596

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18597
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18597

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18598
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18598

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18599
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18599

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18600
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18600

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18601
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18601

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18602
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18602

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18603
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18603

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18604
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18604

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18605
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18605

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18606
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18606

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18607
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18607

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18608
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18608

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18609
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18609

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18610
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18610

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18611
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18611

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18612
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18612

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18613
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18613

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18614
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18614

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18615
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18615

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18616
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18616

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18617
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18617

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18618
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18618

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18619
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18619

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18620
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18620

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18621
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18621

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18622
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18622

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18623
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18623

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18624
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18624

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18625
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18625

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18626
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18626

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18627
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18627

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18628
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18628

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18629
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18629

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18630
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18630

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18631
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18631

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18632
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18632

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18633
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18633

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18634
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18634

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18635
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18635

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18636
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18636

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18637
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18637

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18638
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18638

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18639
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18639

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18640
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18640

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18641
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18641

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18642
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18642

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18643
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18643

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18644
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18644

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18645
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18645

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18646
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18646

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18647
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18647

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18648
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18648

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18649
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18649

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18650
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18650

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18651
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18651

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18652
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18652

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18653
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18653

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18654
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18654

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18655
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18655

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18656
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18656

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18657
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18657

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18658
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18658

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18659
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18659

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18660
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18660

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18661
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18661

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18662
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18662

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18663
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18663

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18664
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18664

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18665
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18665

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18666
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18666

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18667
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18667

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18668
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18668

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18669
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18669

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18670
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18670

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18671
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18671

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18672
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18672

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18673
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18673

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18674
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18674

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18675
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18675

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18676
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18676

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18677
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18677

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18678
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18678

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18679
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18679

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18680
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18680

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18681
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18681

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18682
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18682

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18683
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18683

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18684
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18684

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18685
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18685

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18686
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18686

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18687
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18687

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18688
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18688

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18689
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18689

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18690
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18690

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18691
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18691

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18692
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18692

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18693
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18693

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18694
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18694

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Asp Ala Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Ser Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18695
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18695

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18696
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18696

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18697
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18697

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18698
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18698

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18699
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18699

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18700
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18700

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18701
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18701

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18702
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18702

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18703
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18703

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18704
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18704

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18705
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18705

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18706
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18706

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18707
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18707

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18708
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18708

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18709
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18709

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18710
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18710

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Glu Ala Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18711
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18711

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18712
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18712

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Glu Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18713
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18713

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18714
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18714

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Gln 
                165                 170                 175     


Ala Ala His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18715
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18715

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45              


Phe Asn Leu Arg Met Lys Ala Asp Thr Ser Leu Phe Ser Ala Glu Phe 
    50                  55                  60                  


Lys Val Glu Thr Ser Asn Lys Val Leu Asp Tyr Asp Thr Ser His Ile 
65                  70                  75                  80  


Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly Ser Phe Ser His Gly Ser 
                85                  90                  95      


Val Ile Asp Gly Arg Phe Glu Gly Phe Ile Gln Thr Arg Gly Gly Thr 
            100                 105                 110         


Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile Lys Asp Arg Thr Leu Pro 
        115                 120                 125             


Phe His Ser Val Ile Tyr His Glu Ala Asp Ile Asn Tyr Pro His Lys 
    130                 135                 140                 


Tyr Gly Pro Gln Gly Gly Cys Ala Asp His Ser Val Phe Glu Arg Met 
145                 150                 155                 160 


Arg Lys Tyr Gln Met Thr Gly Val Ala Glu Val Thr Gln Ile Pro Ala 
                165                 170                 175     


Glu Glu His Ala Ala Asn Gly Pro Glu Leu Leu Arg Lys 
            180                 185                 


<210>  18716
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized modified ADAM10 peptide

<400>  18716

Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr Glu Gly Leu Ser Tyr Asn 
1               5                   10                  15      


Val Asp Ser Leu His Gln Lys His Gln Arg Ala Lys Ala Ala Val Ser 
            20                  25                  30          


His Glu Asp Ala Phe Leu Arg Leu Asp Phe His Ala His Gly Arg His 
        35                  40                  45         